Feeling more tired, sleeping differently, noticing changes in where you carry weight, or experiencing a drop in libido can make you wonder whether you are simply getting older. The body naturally changes with age, but shifts in estrogen or testosterone can cause concerns that are easy to dismiss as part of getting older. Through Pellecome®, […]
A hormone result can fall inside a laboratory reference interval and still require thoughtful interpretation. These ranges are based on defined populations, while hormone measurements can vary with age, sex, time of day, assay method, medications, binding proteins, and physiologic state. Research on endocrine testing has shown that differences among assays and reference intervals can […]
Pregnenolone sits early in the steroid hormone pathway, where it helps supply the building blocks for several downstream hormones. Because of that upstream role, pregnenolone can be clinically relevant when providers are evaluating stress response, reproductive hormones, and broader endocrine balance.¹ Pellecome®, founded by Enrique G. Jacome, MD, FACOG, supports healthcare providers with evidence-informed BHRT solutions, advanced delivery methods, […]
Hormonal imbalance can affect sleep, mood, energy, metabolism, libido, body composition, and overall comfort. For many women, symptoms begin gradually during perimenopause or menopause, while others notice changes after pregnancy, surgery, stress, medical treatment, or shifts in daily health routines. Pellecome®, founded by Enrique G. Jacome, MD, FACOG, supports provider-guided Bio-Identical Hormone Replacement Therapy (BHRT) through high-quality hormone […]
Hormone therapy requires follow-up after initial dosing. The first treatment plan provides a clinical starting point, but response can vary based on baseline hormone status, absorption, metabolism, symptoms, lifestyle factors, and route of administration. Current clinical guidance reinforces the need for individualized monitoring. The Menopause Society notes that hormone therapy decisions should be individualized and […]
Metabolism can change gradually, and it is not always easy to tell when something has shifted. Many people first notice that familiar routines no longer seem to work the same way: weight feels harder to manage, energy dips more often, cravings become stronger, or recovery takes longer after activity. Metabolic health depends on many systems, […]
Hot summer weather can make anyone feel drained, sweaty, or uncomfortable. But if you feel unusually sensitive to heat, wake up with night sweats, or notice sudden waves of warmth that seem to come out of nowhere, there may be more going on than the temperature outside. Shifting hormone levels can change how the body […]
When male patients present with fatigue, reduced libido, poor recovery, changes in body composition, or low motivation, testosterone is often part of the clinical conversation. While age-related hormonal decline is an important consideration, lifestyle factors can also shape how patients feel and how clinicians interpret symptoms and lab findings. Regular alcohol use is one lifestyle […]
When patients present with fatigue, poor stress tolerance, or cognitive complaints, clinicians often investigate endocrine contributors such as cortisol dysregulation, thyroid dysfunction, or metabolic abnormalities. However, hydration status may be an overlooked factor influencing many of these symptoms. Fluid balance is regulated through several endocrine pathways, including cortisol, aldosterone, and the renin-angiotensin-aldosterone system (RAAS). Even […]
If you regularly find yourself feeling sluggish a few hours after lunch, you’re not alone. Afternoon energy crashes are a common complaint, often bringing symptoms such as fatigue, brain fog, irritability, or difficulty concentrating. While a busy schedule or lack of sleep can certainly contribute, recurring afternoon fatigue may also be influenced by blood sugar […]
