Diindolylmethane (DIM) and Indole-3-carbinol (I3C) are supplements that support proper estrogen metabolism. Naturally derived from cruciferous vegetables such as broccoli, cauliflower, kale, and cabbage, DIM I3C impacts different cellular activities that support healthy hormone levels.
Safe and effective, DIM I3C supplements have been shown to be beneficial for breast and prostate health and can be incredibly useful for both men and women.
To learn more about DIM I3C supplementation, please find a Pellecome provider in your area and schedule a one-on-one consultation today. Pellecome has created a line of scientifically-backed supplements available only through healthcare providers.
What Is the DIM I3C Supplement?
DIM is a phytonutrient and plant indole. It helps enhance the cells' antioxidant potential and supports the formation of healthy estrogen metabolites.
I3C is a naturally occurring compound converted into DIM by the body. Working in conjunction with DIM, I3C can:
- Reduce cellular overstimulation
- Temper estrogen signals
- Support healthy cellular function
- Improve acne
- Protect against certain types of cancer (including breast, cervical, prostate, and colon cancer)1
The DIM I3C supplement from Pellecome contains carefully measured doses of both beneficial metabolites, allowing easy, once-daily dosing to provide optimal benefits.
How Does the Supplement Work?
There are many different estrogen metabolites. Some, such as 2-hydroxyestrone (2-OHE), help to protect cells against damage. Others, including 4-hydroxyestrone (4-OHE) and 16-alpha-hydroxyestrone (16-alpha-OHE), can overstimulate the cells, cause free radical damage, and damage DNA.
The active ingredients in the DIM I3C supplement from Pellecome synergistically combine to produce the protective 2-OHE metabolite, creating a healthier ratio of 2-OHE to 16-alpha-OHE, and helping to protect and improve breast and prostate health.2
Why Estrogen Balance Matters
Estrogen is essential for proper organ functioning. It also plays a role in bone health, fat distribution, cognitive health, reproductive health, proper cardiovascular functioning, and more in both women and men.
An estrogen imbalance can result in many complications, including:
- Irregular Menstruation (low or heavy flow)
- Sleeping Problems
- Mood Disorders (including mania)
- Diminished Sexual Desire
- Weight Gain
- Fatigue
- Dry Skin
Balancing estrogen levels helps prevent these complications and treat those already present, but optimal results may require supplementation with BHRT. Your healthcare provider will be able to provide you with additional information on these treatments to assist in finding the right combination for your needs.
Benefits of DIM I3C for Men and Women
Although estrogen is often associated with women, it plays an important role in the health of both sexes.
For women, balanced estrogen metabolism may help support:
- Healthy menstrual cycles
- Breast tissue health
- Skin clarity
- Mood stability
- Healthy weight distribution
Men produce lower levels of estrogen than women, but excess estrogen activity can still contribute to unwanted symptoms. DIM I3C may help support:
- Prostate health
- Healthy testosterone-to-estrogen balance
- Lean body composition
- Energy levels
- Hormonal stability as men age
Who Is an Ideal Candidate for DIM I3C Supplements?
If you have been diagnosed with estrogen dominance, you may be a good DIM I3C candidate. This supplement may also help patients maintain already healthy estrogen levels or support those undergoing different types of hormone replacement therapy.
DIM I3C is naturally derived from food sources and comes with few risks. This supplement is considered safe for use by most people. However, it is always important to talk to a healthcare provider before beginning supplementation to ensure it is both necessary and safe.
What Makes Our DIM I3C Supplement Different?
Our DIM I3C supplement is manufactured to our exacting standards and designed for optimal efficacy. Free of fish and animal byproducts, our DIM I3C supplement contains no allergens, sweeteners, or artificial flavors and is safe for vegetarians.
Pellecome stands fully behind all of the products we manufacture.
Founded by Dr. Enrique G. Jacome, a board-certified and award-winning OB-GYN, Pellecome is dedicated to helping men and women find optimal health and happiness through hormonal balance. Use our provider locator to find a doctor in your area, schedule a consultation, and find out how our products can help you live your best life.
Does DIM I3C Have Any Side Effects?
Just like any other medication or supplement, DIM I3C comes with a few side effects that patients should be aware of.
The most common side effects include headaches, nausea, vomiting, gas, and diarrhea. Because DIM I3C works to detoxify the body naturally, patients may also experience side effects of bodily detox, which can include fatigue, brain fog, darkened urine, increased bowel movements, and skin rash.
However, as you take your supplements daily, your body can adjust to them. After your first detox, and the more your body gets used to DIM I3C, these side effects may subside.
Why Choose Pellecome?
Pellecome was founded by Enrique G. Jacome, MD, FACOG, a board-certified OB-GYN who has specialized in hormone replacement therapy since 1995. After years of clinical experience, he focused on advancing bio-identical hormone pellet therapy and improving how hormones are delivered and managed in practice. He has personally placed more than 30,000 hormone pellet implants and has worked extensively to refine both the insertion technique and the therapeutic process. That hands-on experience shapes the development of Pellecome’s supplement line, which is designed to complement hormone care under medical supervision.
Pellecome also supports healthcare professionals through structured education and training led by experienced clinicians. With leadership that includes national trainers and professionals with backgrounds in functional medicine, nursing, and product development, the company emphasizes practitioner-guided care rather than over-the-counter solutions.
Supplements are available exclusively through healthcare providers, helping ensure that use is individualized, monitored, and aligned with a patient’s broader hormone management plan.
Frequently Asked Questions
Does DIM I3C Have Any Effects on the Liver?
Yes, DIM I3C has positive effects on the liver, as the supplement’s encouragement for a natural detoxification process can help clear the liver of toxins the body has absorbed. Through this process, as well as the increased amount of estrogen that can be produced when taking the supplement, DIM I3C can protect the liver against conditions such as viral hepatitis, hepatic steatosis, hepatic cirrhosis, hepatocellular carcinoma, and more.3
Who Should Not Take DIM I3C?
DIM I3C is not recommended for patients who are pregnant, nursing, or planning to become pregnant. If you are on any type of birth control medication, you may still be a candidate for taking DIM I3C, but we recommend consulting your doctor, as birth control can often alter the results of DIM I3C on the body.
DIM I3C may not be as beneficial to women who have reached menopause since their bodies begin to produce less estrogen. It’s important to note that DIM I3C works best as a supplement and is not an estrogen replacement.
How Much Does DIM I3C Cost?
DIM I3C can cost anywhere between $25 to $50 for a full bottle. If taken one to two times daily with food, the average bottle can last a patient about one month.
Avoiding foods and drinks extremely high in sugar, such as candy, cookies, soda, and fruit juice, as well as processed foods, can help decrease the amount of toxins and fat buildup in the liver, allowing for more balanced hormones and optimal health while taking DIM I3C.
Can DIM I3C Be Taken Alongside Bioidentical Hormone Replacement Therapy?
DIM influences how estrogen is metabolized, not how much estrogen is produced or administered. Because BHRT provides exogenous hormones and DIM affects estrogen metabolism pathways, they may be used together under medical supervision.
That said, DIM can shift estrogen metabolite ratios, which may alter lab results or symptom response in patients using BHRT. For that reason, co-administration should be guided by a qualified provider who is monitoring hormone levels and clinical response.
What Is the Difference Between DIM Alone and a DIM + I3C Formula?
Indole-3-carbinol (I3C) is a compound found in cruciferous vegetables. When consumed, I3C is converted in the stomach into several compounds, including DIM. DIM is considered one of the primary bioactive metabolites responsible for many of I3C’s biological effects.
A DIM-only supplement provides the already-converted compound in a stable form. A DIM + I3C formula provides both DIM and the precursor compound that can convert into DIM and other indole derivatives in the body.
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Learn More About DIM I3C Today
Founded by Dr. Enrique G. Jacome, a board-certified and award-winning OBGYN, Pellecome is dedicated to helping men and women find optimal health and happiness through hormonal balance. Use our provider locator to find a doctor in your area, schedule a consultation, and find out how our products can help you live your best life.
- Reyes-Hernández OD, Figueroa-González G, Quintas-Granados LI, Gutiérrez-Ruíz SC, Hernández-Parra H, Romero-Montero A, et al. 3,3’-Diindolylmethane and indole-3-carbinol: potential therapeutic molecules for cancer chemoprevention and treatment via regulating cellular signaling pathways. Cancer Cell Int [Internet]. 2023;23(1):180. Available from: http://dx.doi.org/10.1186/s12935-023-03031-4
- Rajoria S, Suriano R, Parmar PS, Wilson YL, Megwalu U, Moscatello A, et al. 3,3’-diindolylmethane modulates estrogen metabolism in patients with thyroid proliferative disease: a pilot study. Thyroid [Internet]. 2011;21(3):299–304. Available from: http://dx.doi.org/10.1089/thy.2010.0245
- Tian C, Deng S, Yang M, Bai B, Pan Y, Xie G, et al. Indole-3-carbinol and its main derivative 3,3’-diindolylmethane: Regulatory roles and therapeutic potential in liver diseases. Biomed Pharmacother [Internet]. 2024;180(117525):117525. Available from: http://dx.doi.org/10.1016/j.biopha.2024.117525
