DIM I3C Supplement for Estrogen Metabolism

Diindolylmethane (DIM) Indole-3-carbinol (I3C) is a supplement that supports proper estrogen metabolism. Naturally derived from cruciferous vegetables such as broccoli, cauliflower, kale, and cabbage, DIM I3C impacts different cellular activities that support healthy hormone levels.

Safe and effective, DIM I3C supplements have shown to be beneficial for breast and prostate health and can be incredibly useful for both men and women.


To learn more about DIM I3C supplementation, please find a Pellecome provider in your area and schedule a one-on-one consultation today. Pellecome has created a line of scientifically-backed supplements available only through healthcare providers.

What is the DIM I3C Supplement?

DIM is a phytonutrient and plant indole. It works to improve the potential of antioxidant activity within the cells and supports the formation of healthy estrogen metabolites.

I3C is a naturally occurring compound converted into DIM by the body. Working in conjunction with DIM, I3C can:

  • Reduce Cellular Overstimulation
  • Temper Estrogen Signals
  • Support Healthy Cellular Function
  • Improve Acne
  • Protect Against Certain Types of Cancer (including breast, cervical, prostate, and colon cancer)

The DIM I3C supplement from Pellecome contains carefully measured doses of both beneficial metabolites, allowing easy, once-daily dosing to provide optimal benefits.

How Does the Supplement work?

There are many different estrogen metabolites. Some, such as 2-hydroxeystrone (2-OHE), help to protect cells against damage. Others, including 4-hydroxyestrone (4-OHE) and 16-alpha-hydroxyestrone (16-alpha-OHE), can overstimulate the cells, cause free radical damage, and damage DNA.

The active ingredients in the DIM I3C supplement from Pellecome synergistically combine to produce the protective 2-OHE metabolite, creating a healthier ratio of 2-OHE to 16-alpha-OHE, and helping to protect and improve breast and prostate health.

How is the Supplement Beneficial?

Estrogen is essential for proper organ functioning. It also plays a role in bone health, fat distribution, cognitive health, reproductive health, proper cardiovascular functioning, and more in both women and men.

An estrogen imbalance can result in many complications, including:

  • Irregular Menstruation (low or heavy flow)
  • Sleeping Problems
  • Mood Disorders (including mania)
  • Diminished Sexual Desire
  • Weight Gain
  • Fatigue
  • Dry Skin

Balancing estrogen levels helps prevent these complications and treat those already present, but optimal results may require supplementation with BHRT. Your healthcare provider will be able to provide you with additional information on these treatments to assist in finding the right combination for your needs.

Who is an Ideal Candidate to Take the DIM I3C Supplement?

If you have been diagnosed with estrogen dominance, you may be a good DIM I3C candidate. This supplement may also help patients maintain already healthy estrogen levels or support those undergoing different types of hormone replacement therapy.

DIM I3C is naturally derived from food sources and comes with few risks. This supplement is considered safe for use by most people. However, it is always important to talk to a healthcare provider before beginning supplementation to ensure it is both necessary and safe.

What Makes Our DIM I3C Supplement Different?

Our DIM I3C supplement is manufactured to our exacting standards and designed for optimal efficacy. Free of fish and animal byproducts, our DIM I3C supplement contains no allergens, sweeteners, or artificial flavors and is safe for vegetarians.

Pellecome stands fully behind all of the products we manufacture.

Founded by Dr. Enrique G. Jacome, a board-certified and award-winning OBGYN, Pellecome is dedicated to helping men and women find optimal health and happiness through hormonal balance. Use our provider locator to find a doctor in your area, schedule a consultation, and find out how our products can help you live your best life.

Does DIM I3C Have Any Side Effects?

Just like any other medication or supplement, DIM I3C comes with a few side effects that patients should be aware of. The most common side effects include headaches, nausea, vomiting, gas, and diarrhea. Because DIM I3C works to detoxify the body naturally, patients may also experience side effects of bodily detox, which can include fatigue, brain fog, darkened urine, increased bowel movements, and skin rash. However, as you take your supplements daily, your body can adjust to it. After your first detox, and the more your body gets used to DIM I3C, these side effects may no longer affect you over time.

Who Should Not Take DIM I3C?

DIM I3C is not recommended for patients who are pregnant, nursing, or planning to become pregnant. If you are on any type of birth control medication, you may still be a candidate for taking DIM I3C, but we recommend consulting your doctor as birth control can often alter the results of DIM I3C on the body. DIM I3C may not be as beneficial to women who have reached menopause since their bodies begin to produce less estrogen. It’s important to note that DIM I3C works best as a supplement and is not an estrogen replacement.

How Much Does DIM I3C Cost?

DIM I3C can cost anywhere between $25 to $50 for a full bottle. If taken one to two times daily with food, the average bottle can last a patient about one month.

Why Is DIM Considered a Novel Food in the UK?

A novel food is considered a food that does not have a significant history of consumption or is produced by a method that has not previously been used for food. In the UK, the European Commission defines novel food as “food that had not been consumed to a significant degree by humans in the EU before 15 May 1997.” Because of this, DIM is often hard to find in stores and online, despite the benefits the supplement can provide.

Does DIM I3C Have Any Effects on the Liver?

Yes, DIM I3C has positive effects on the liver as the supplement’s encouragement for a natural detoxification process can help clear the liver of toxins the body has absorbed. Through this process, as well as the increased amount of estrogen that can be produced when taking the supplement, DIM I3C can protect the liver against conditions such as viral hepatitis, hepatic steatosis, hepatic cirrhosis, hepatocellular carcinoma, and more.

Avoiding foods and drinks extremely high in sugar, such as candy, cookies, soda, and fruit juice, as well as processed foods, can help decrease the amount of toxins and fat buildup in the liver, allowing for more balanced hormones and optimal health while taking DIM I3C.

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Schedule a Consultation With Dr. Jacome To Learn More About DIM 13C Today

Founded by Dr. Enrique G. Jacome, a board-certified and award-winning OBGYN, Pellecome is dedicated to helping men and women find optimal health and happiness through hormonal balance. Use our provider locator to find a doctor in your area, schedule a consultation, and find out how our products can help you live your best life.

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