Hormonal imbalance can affect sleep, mood, energy, metabolism, libido, body composition, and overall comfort. For many women, symptoms begin gradually during perimenopause or menopause, while others notice changes after pregnancy, surgery, stress, medical treatment, or shifts in daily health routines.
Pellecome®, founded by Enrique G. Jacome, MD, FACOG, supports provider-guided Bio-Identical Hormone Replacement Therapy (BHRT) through high-quality hormone pellets, clinical education, and advanced delivery methods. Dr. Jacome is a board-certified OB-GYN with extensive experience in women’s health, hormone therapy, minimally invasive surgery, and pellet insertion therapy.
The right option depends on what is driving the symptoms, along with your health history, lab findings, age, and treatment goals. Prescription medications, BHRT, supplements, and lifestyle strategies can each play a different role.
Prescription Options for Hormonal Imbalance
Prescription hormone therapy is commonly used to help manage menopause-related symptoms such as hot flashes, night sweats, vaginal dryness, sleep disruption, and discomfort with sex. The Menopause Society notes that hormone therapy remains the most effective treatment for vasomotor symptoms and genitourinary syndrome of menopause, and that treatment decisions should be individualized based on factors such as dose, duration, route, timing, and patient-specific risks.¹
Prescription options may include:
- Estrogen therapy: Often used for hot flashes, night sweats, vaginal dryness, and other menopause symptoms.
- Progesterone or progestin: Usually recommended with systemic estrogen for women who still have a uterus.
- Local vaginal therapy: May be considered for vaginal dryness, irritation, urinary discomfort, or painful sex.
- Nonhormonal prescription medications: Some women who cannot or do not want to use hormone therapy may be offered options such as certain antidepressants, gabapentin, oxybutynin, or other nonhormonal medications for hot flashes.²
These medications should be chosen with a clinician who can review your risks, symptoms, and goals. Concerns that seem hormone-related can overlap with thyroid conditions, stress, medication effects, nutrient deficiencies, sleep disorders, and other medical issues.
Where Provider-Guided BHRT Fits
BHRT uses hormones that are structurally similar to hormones naturally produced by the body. Pellecome focuses on bio-identical hormone pellets, which are placed by trained clinicians and designed to release hormones gradually over time.
For women exploring hormone therapy, women’s hormone health education can be a helpful starting point. A provider can review symptoms, labs, health history, and risk factors to determine whether BHRT fits your health profile or whether another option makes more sense.
Pellecome does not replace medical evaluation. It supports trained providers with BHRT products, education, and resources designed to help guide personalized hormone care.
Natural Options That May Support Hormone Health
Natural options can support overall hormone health, but they should not replace medical evaluation when symptoms are persistent or disruptive. Complementary health research shows mixed results for many natural products used for menopause symptoms, and some supplements may interact with medications or carry safety concerns.³
Supportive strategies may include:
- Eating balanced meals with protein, fiber, and healthy fats
- Prioritizing sleep and stress management
- Strength training to support muscle and bone health
- Reducing alcohol and highly processed foods
- Addressing nutrient gaps with medical guidance
- Reviewing supplement options based on symptoms and lab findings
Pellecome offers targeted products such as DIM I3C for estrogen metabolism support, Vitamin D3 and K2 for musculoskeletal wellness support, and DHEA 25mg as part of clinician-guided hormone and stress-support protocols. These options are not right for everyone and should be discussed with a healthcare professional before use.
Finding the Right Option for You
There is no single best medication for every woman with hormonal imbalance. Some women may benefit from prescription hormone therapy, some may need nonhormonal medications, and others may do best with BHRT, supplements, and lifestyle support as part of a broader care plan.
If hot flashes, fatigue, poor sleep, mood changes, low libido, or body composition changes are affecting your quality of life, a trained provider can help clarify what is happening and which options are worth reviewing.
Pellecome® supports qualified healthcare professionals with evidence-informed BHRT solutions and education designed to promote individualized care. Use the Pellecome® Provider Locator to connect with a qualified provider in your area.
- “The 2022 Hormone Therapy Position Statement of The North American Menopause Society” Advisory Panel. The 2022 hormone therapy position statement of The North American Menopause Society. Menopause [Internet]. 2022;29(7):767–94. Available from: http://dx.doi.org/10.1097/GME.0000000000002028
- “The 2023 Nonhormone Therapy Position Statement of The North American Menopause Society” Advisory Panel. The 2023 nonhormone therapy position statement of The North American Menopause Society. Menopause [Internet]. 2023;30(6):573–90. Available from: http://dx.doi.org/10.1097/GME.0000000000002200
- Menopausal symptoms and complementary health approaches [Internet]. NCCIH. [cited 2026 Aug 4]. Available from: https://www.nccih.nih.gov/health/providers/digest/menopausal-symptoms-and-complementary-health-approaches
