September 2026

Pregnenolone sits early in the steroid hormone pathway, where it helps supply the building blocks for several downstream hormones. Because of that upstream role, pregnenolone can be clinically relevant when providers are evaluating stress response, reproductive hormones, and broader endocrine balance.¹ Pellecome®, founded by Enrique G. Jacome, MD, FACOG, supports healthcare providers with evidence-informed BHRT solutions, advanced delivery methods,

Hormonal imbalance can affect sleep, mood, energy, metabolism, libido, body composition, and overall comfort. For many women, symptoms begin gradually during perimenopause or menopause, while others notice changes after pregnancy, surgery, stress, medical treatment, or shifts in daily health routines. Pellecome®, founded by Enrique G. Jacome, MD, FACOG, supports provider-guided Bio-Identical Hormone Replacement Therapy (BHRT) through high-quality hormone