What Is Estrogen Dominance?

When it comes to leading a good life, balance is key. This is certainly the case with hormones. If your hormone levels are not properly balanced, it could lead to a variety of issues. One of the most common types of hormonal imbalance in women is estrogen dominance¹, and it can have a major effect on your quality of life and overall well-being. Let’s take a closer look.

Estrogen Dominance and Progesterone Deficiency Explained

Women who suffer from estrogen dominance¹—meaning they have high estrogen levels—typically don’t produce enough progesterone, which is another type of sex hormone found in females.

Progesterone² plays a crucial role in menstrual cycles and pregnancy, among other things. Furthermore, it regulates the impact of estrogen on the body by reducing the number of receptors estrogen can bind to.³ This reduces the effect estrogen has on specific organs.

If your body doesn’t produce enough progesterone, it won’t be able to keep estrogen production at a healthy level.

The Impacts of Estrogen Dominance on Your Body

Hormones act as direct messengers for your organs to do various functions. Hormones can have a major impact on your metabolism, mood, energy levels, sex drive, and more.⁴ Unfortunately, estrogen dominance can have many negative effects on your body and well-being.¹

Women who suffer from estrogen dominance may experience bloating and excess fat around their thighs, hips, and stomach.⁵ Mood swings may also be common, and premenstrual syndrome (PMS) symptoms can be more severe.⁶

As you can imagine, these symptoms can have a massively negative impact on your quality of life. Unfortunately, estrogen dominance will often not clear up on its own. Your body can fight off colds and heal cuts and other injuries. If there’s a problem with your hormone levels, however, external intervention is often needed to achieve balance.

Treating Estrogen Imbalance With DIM I3C From Pellecome®

Diindolylmethane (DIM) Indole-3-carbinol (I3C), or DIM I3C for short, can regulate your hormones and treat the symptoms of estrogen dominance. DIM I3C from Pellecome is derived naturally from plants⁷ and is safe to use under proper guidance.

If you need help with estrogen dominance or would like to learn more about DIM I3C, contact Pellecome at 888-773-9969 or use our online tool to find a Pellecome provider near you.

  1. Estrogen Dominance – Whole Health Library [Internet]. Available from:
  2. Estrogen and Progesterone: Reasons to Balance Levels [Internet]. Verywell Health. Available from:
  3. ‌Jayaraman A, Pike CJ. Progesterone Attenuates Oestrogen Neuroprotection Via Downregulation of Oestrogen Receptor Expression in Cultured Neurones. Journal of Neuroendocrinology. 2009 Jan;21(1):77–81.
  4. ‌Hiller-Sturmhöfel S, Bartke A. The endocrine system: an overview. Alcohol Health and Research World [Internet]. 1998;22(3):153–64. Available from:
  5. Hormonal belly: Causes and treatment [Internet]. 2020. Available from:
  6. Holland K. Signs and Symptoms of High Estrogen [Internet]. Healthline. Healthline Media; 2015. Available from:
  7. Le HT, Schaldach CM, Firestone GL, Bjeldanes LF. Plant-derived 3,3′-Diindolylmethane Is a Strong Androgen Antagonist in Human Prostate Cancer Cells. Journal of Biological Chemistry. 2003 Mar 27;278(23):21136–45.

Accessibility Toolbar

Two Part Training Seminar (Option 1)

Hands-On Training

April 27, 2024 - Newport Beach, CA 

June 8 - Melbourne, FL