Optimizing Patient Health: Why Providers Should Recommend DIM I3C Supplements

Healthcare providers are increasingly turning to natural supplements to meet the growing demand for holistic care. DIM I3C is emerging as a powerful tool for promoting hormone balance and overall health.

Led by board-certified OB-GYN Dr. Enrique G. Jacome, Pellecome offers high-quality DIM I3C supplements. Whether your patients are undergoing hormone therapy or simply looking to maintain a healthy balance, DIM I3C provides a convenient solution.

The Science Behind DIM and I3C

DIM (Diindolylmethane) and I3C (Indole-3-Carbinol) are compounds found in cruciferous vegetables like broccoli, Brussels sprouts, and kale.¹ When consumed, I3C is converted into DIM in the stomach. DIM then helps balance estrogen levels in the body, which is important for maintaining health.

DIM I3C Benefits for Overall Health

DIM I3C supplements offer a wide range of benefits, making them a valuable addition to your patients’ health routines. These benefits include:

• Hormone Balance: Helps maintain a healthy ratio of estrogen to testosterone in men and estrogen to progesterone in women, reducing symptoms like mood swings, hot flashes, and low libido while also supporting overall energy levels and mental clarity.² 
• Weight Management: DIM may help inhibit the formation of fat cells and reduce diet-induced obesity by targeting specific proteins involved in fat storage.³ 
• Cancer Prevention: May lower the risk of hormone-related cancers, offering added protection for your patients.¹ 
• Prostate Health: May support prostate function and help protect against hormone-related prostate issues.⁴
• Detoxification: Supports the body’s natural detoxification processes, helping to eliminate harmful toxins and reduce oxidative stress.⁵
• Immune Support: Contains antioxidant properties that protect cells from damage, reduce inflammation, and support overall immune health.⁶

For patients undergoing Bio-Identical Hormone Replacement Therapy (BHRT), DIM I3C can further enhance treatment results by promoting optimal hormone balance and reducing potential side effects. However, these supplements are beneficial for anyone looking to improve their health naturally.

Supporting Patient Health With DIM I3C Supplements

Recommending DIM I3C supplements is a simple way for healthcare providers to support their patients’ overall health and hormone balance. This is especially true if a patient struggles to get enough nutrients through food sources. These supplements are easy to incorporate into daily routines and offer clear, tangible benefits.

Pellecome provides healthcare professionals with high-quality DIM I3C supplements. We’ll help you deliver the best care to your patients with solutions for long-term health. 

To learn more about how Pellecome can support your practice with DIM I3C supplements, call us at 888-462-7097 or fill out our online form.

1. Thomson CA, Ho E, Strom MB. Chemopreventive properties of 3,3′-diindolylmethane in breast cancer: evidence from experimental and human studies. Nutr Rev [Internet]. 2016 [cited 2024 Aug 21];74(7):432–43. Available from: http://dx.doi.org/10.1093/nutrit/nuw010
2. Rubinow KB. Estrogens and body weight regulation in men. In: Advances in Experimental Medicine and Biology [Internet]. Cham: Springer International Publishing; 2017 [cited 2024 Aug 21]. p. 285–313. Available from: http://dx.doi.org/10.1007/978-3-319-70178-3_14
3. Yang H, Seo SG, Shin SH, Min S, Kang MJ, Yoo R, et al. 3,3’‐Diindolylmethane suppresses high‐fat diet‐induced obesity through inhibiting adipogenesis of pre‐adipocytes by targeting USP2 activity. Mol Nutr Food Res [Internet]. 2017 [cited 2024 Aug 21];61(10). Available from: https://pubmed.ncbi.nlm.nih.gov/28586165/ 
4. Paltsev M, Kiselev V, Drukh V, Muyzhnek E, Kuznetsov I, Andrianova E, et al. First results of the double-blind randomized placebo-controlled multicenter clinical trial of DIM-based therapy designed as personalized approach to reverse prostatic intraepithelial neoplasia (PIN). EPMA J [Internet]. 2016 [cited 2024 Aug 21];7(1). Available from: http://dx.doi.org/10.1186/s13167-016-0057-3 
5. Munakarmi S, Chand L, Shin HB, Jang KY, Jeong YJ. Indole-3-carbinol derivative DIM mitigates carbon tetrachloride-induced acute liver injury in mice by inhibiting inflammatory response, apoptosis and regulating oxidative stress. Int J Mol Sci [Internet]. 2020 [cited 2024 Aug 21];21(6):2048. Available from: https://www.mdpi.com/1422-0067/21/6/2048
6. Fan S, Meng Q, Xu J, Jiao Y, Zhao L, Zhang X, et al. DIM (3,3′-diindolylmethane) confers protection against ionizing radiation by a unique mechanism. Proc Natl Acad Sci U S A [Internet]. 2013;110(46):18650–5. Available from: http://dx.doi.org/10.1073/pnas.1308206110