menopause and bone health

Menopause and Bone Health

One in three women over the age of 50 years will experience bone fractures due to osteoporosis in their lifetime.¹ Most women enter menopause between the ages of 45 and 55.² Whether you are nearing menopause or presently living with menopause symptoms, there is no better time than now to start protecting your bone health. Here is what you need to know.

How Menopause Affects Bone Health

Estrogen plays a crucial role in slowing down the natural process of bone breakdown.³ However, estrogen levels rise and fall throughout menopause because of the body’s response to the natural aging process. When enough estrogen declines during menopause, it can pose serious risks to your bone health.³

Osteoporosis is a skeletal disease that can result from negative changes in your body’s bone structure and strength.⁴ As a result of having this disease, you may be more prone to breaking or fracturing your bones.⁴

Preventing Osteoporosis With BHRT

Postmenopausal osteoporosis is the most common metabolic bone disease, and a lack of estrogen plays a key role in its progression.⁵ Bioidentical hormone replacement therapy (BHRT) using estrogen is one method of preventing osteoporosis and reducing the risk of bone fractures.⁶

BHRT uses hormones that are identical on a molecular level to the natural hormones in your body. As such, it is often more easily absorbed and safer than other synthetic hormone therapies.

Typically, this treatment uses a combination of estrogen and progestin to effectively lower the risk of uterine cancer, which may otherwise increase when there is only estrogen.⁷

Explore Your Options With BHRT

BHRT for menopause symptoms employs a diverse range of formulations, ensuring you have options that suit your specific needs. These products include gels, patches, pills, or pellets implanted beneath the skin.

Subdermal implants have been shown to be a useful and effective way of administering hormones since they have the potential to provide more consistent therapeutic results than alternative delivery techniques.⁸

Pellecome manufactures a variety of solutions, including BHRT pellets, which you can access through a number of different BHRT providers.

Search for a BHRT Provider Near You

Combat the effects of menopause and prevent osteoporosis by getting access to BHRT from Pellecome. Click here to find a qualified BHRT provider near you, or contact (888) 773-9969 for more information about Pellecome.

  1. Sozen T, Ozisik L, Calik Basaran N. An overview and management of osteoporosis. European Journal of Rheumatology. 2017 Mar 1;4(1):46–56. Available from:
  1. National Institute on Aging. What Is Menopause? [Internet]. National Institute on Aging. 2021. Available from:
  1. Endocrine Society. Menopause and Bone Loss [Internet]. 2022. Available from:
  1. National Institute of Arthritis and Musculoskeletal and Skin Diseases. Osteoporosis [Internet]. National Institute of Arthritis and Musculoskeletal and Skin Diseases. 2019. Available from:
  1. Gambacciani M, Levancini M. Featured Editorial Hormone replacement therapy and the prevention of postmenopausal osteoporosis. Menopausal Review [Internet]. 2014;13(4):213–20. Available from:
  1. Abdi F, Mobedi H, Bayat F, Mosaffa N, Dolatian M, Ramezani Tehrani F. The Effects of Transdermal Estrogen Delivery on Bone Mineral Density in Postmenopausal Women: A Meta-analysis. Iranian Journal of Pharmaceutical Research: IJPR [Internet]. 2017;16(1):380–9. Available from:
  1. Menopausal Hormone Therapy and Cancer Risk [Internet]. Available from:
  1. Lin S, Chao P, Chien YW, Sayani A, Kumar S, Mason M, et al. In vitro and in vivo evaluations of biodegradable implants for hormone replacement therapy: Effect of system design and PK-PD relationship. Aaps Pharmscitech [Internet]. 2001 Sep 1 [cited 2023 Sep 22];2(3):55–65. Available from:

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