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What are Pre-Hormones?

The endocrine system is a complex network of glands and organs that produce hormones. These are then secreted through the bloodstream into target organs outside the system to help control the body’s metabolism, stress response, energy levels, healing ability, mood, cognition, and more.

In addition to hormones, the endocrine system produces pre-hormones, glandular sections with no biological activity until they are converted into their active forms within targeted cells. Pre-hormones act as a building block for hormones and are essential for their proper function.

Not all pre-hormones are secreted by the endocrine system, however. Vitamin D3, for example, is converted into calcifediol when hydroxylated by the liver1.


Pregnenolone is a pre-hormone that serves as the starting material for several important hormones, including testosterone, progesterone, cortisol, and estrogen. A pregnenolone deficiency will impact the production of these hormones, a concern that may result in:

  • Stubborn Weight Gain
  • Excessive Fatigue
  • Depressive and Mood Disorders
  • Joint and Muscle Pain
  • Cognition and Memory Difficulties
  • Diminished Sex Drive
  • Hair Loss
  • Dry Skin

If you are experiencing one or more of these issues, you may benefit from pregnenolone supplementation.

Pregnenolone supplements offer a safe and effective way to boost pregnenolone levels and assist the body in producing hormones essential for optimal health. Through regular use under the supervision of a qualified healthcare professional, supplementing with pregnenolone can help improve sexual drive and response, balance the mood, restore cognitive function, improve sleep quality, and more. Bioidentical hormone replacement therapy (BHRT) may enhance or boost these effects to address existing imbalances.

Why Choose Pellecome®?

Pellecome is a leader in the hormone replacement therapy industry. The vision of board-certified Ob-Gyn, Dr. Enrique G. Jacome, Pellecome is dedicated to manufacturing safe and effective products, including clinically-proven supplements and BHRT pellets.

Pellet delivery of BHRT has shown to be safer, more comfortable, more predictable, and more effective than other delivery methods, and our advanced Re Pellet Delivery System is among the most innovative and patient-friendly devices available today. Available only through authorized and specially-selected healthcare partners, our BHRT, supplements, and programs are designed to assist men and women experiencing hormone-related difficulties in finding balance and living their best lives.

If you are struggling with symptoms of hormonal imbalance, please use our provider locator to find a physician in your area and learn more.

  1. Sosa Henríquez M, Gómez de Tejada Romero MJ. Cholecalciferol or Calcifediol in the Management of Vitamin D Deficiency. Nutrients. 2020;12(6):1617. Published 2020 May 31. doi:10.3390/nu12061617, available from

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