At Pellecome, healthy aging is about more than symptom management. It means supporting both the brain and the body as patients grow older. That vision comes from Dr. Enrique G. Jacome, a board-certified Ob-Gyn who has specialized in hormone replacement therapy since the mid-1990s. He created Pellecome to simplify BHRT for providers and improve outcomes for patients.
His work led to the development of an advanced pellet delivery system and a supplement line, including BrainFit, which is part of the PellecomeFIT® BHRT program. Formulated with magnesium L-threonate, the only form of magnesium shown to effectively cross the blood-brain barrier, BrainFit supports mental clarity, memory, and hormonal balance.
For healthcare providers across the nation, this creates an opportunity to expand the way you care for your patients.
Why Brain Health and Hormones Are Linked
As patients age, cognitive changes often occur alongside shifts in hormone levels. Problems with memory, sleep, or mood are frequently tied to these changes.
When brain and hormone health are treated as connected rather than separate concerns, the outcomes improve. BrainFit was formulated with this dual approach in mind, offering support that bridges cognitive performance and hormonal equilibrium.
The Power of Magnesium L-Threonate
The main ingredient in BrainFit is magnesium L-threonate. Unlike other forms of magnesium, this compound can cross the blood-brain barrier. Research has shown that it increases magnesium concentration in the brain, which is linked to neuroplasticity, improved memory, and stronger mental focus.1
Magnesium also plays a role in more than 300 enzymatic reactions throughout the body. It helps regulate neurotransmitters such as dopamine and serotonin, supports GABA receptor activity for calmness, and aids melatonin production for sleep regulation.2
These functions make it central to cognitive performance, emotional stability, and rest.
Dual Benefits for Healthy Aging
Sleep, stress, and mood all influence hormone balance. Studies show that poor sleep can lower testosterone in men and worsen menopausal symptoms in women,3-4 while chronic stress can disrupt normal hormone signaling.5
By supporting better rest and emotional stability, BrainFit may help create conditions where BHRT works more effectively. For providers, this makes BrainFit a practical complement to hormone therapy protocols.
Why Pellecome Stands Out
Pellecome does not require contracts or procedural fees, and we provide full practice support, from ROI analysis to economic planning.
When you combine BrainFit with our BHRT pellet system, you give patients a comprehensive plan for healthier aging. To learn more about incorporating BrainFit into your practice, contact Pellecome at 888-773-9969.
- Liao W, Wei J, Liu C, Luo H, Ruan Y, Mai Y, et al. Magnesium-L-threonate treats Alzheimer’s disease by modulating the microbiota-gut-brain axis. Neural Regen Res [Internet]. 2024;19(10):2281–9. Available from: http://dx.doi.org/10.4103/1673-5374.391310
- Hausenblas HA, Lynch T, Hooper S, Shrestha A, Rosendale D, Gu J. Magnesium-L-threonate improves sleep quality and daytime functioning in adults with self-reported sleep problems: A randomized controlled trial. Sleep Med X [Internet]. 2024;8(100121):100121. Available from: http://dx.doi.org/10.1016/j.sleepx.2024.100121
- Leproult R, Van Cauter E. Effect of 1 week of sleep restriction on testosterone levels in young healthy men. JAMA [Internet]. 2011;305(21):2173–4. Available from: http://dx.doi.org/10.1001/jama.2011.710
- Drake CL, Kalmbach DA, Arnedt JT, Cheng P, Tonnu CV, Cuamatzi-Castelan A, et al. Treating chronic insomnia in postmenopausal women: a randomized clinical trial comparing cognitive-behavioral therapy for insomnia, sleep restriction therapy, and sleep hygiene education. Sleep [Internet]. 2019;42(2). Available from: http://dx.doi.org/10.1093/sleep/zsy217
- Liu PY, Reddy RT. Sleep, testosterone and cortisol balance, and ageing men. Rev Endocr Metab Disord [Internet]. 2022;23(6):1323–39. Available from: http://dx.doi.org/10.1007/s11154-022-09755-4
