Testosterone and Women’s Health: Why Balance Matters at Every Age

Testosterone may not be the first hormone people associate with women’s health, but its role is far more important than many realize. It impacts strength, energy, mental clarity, and sexual vitality — and when levels drop, the effects ripple across nearly every aspect of daily life. 

At Pellecome, founded by Dr. Enrique Jacome in Gladstone, New Jersey, we give healthcare providers the tools and knowledge to treat hormone imbalances. When you recognize the effects of testosterone decline, you have a stronger foundation for guiding your patients toward lasting wellness.

Why Testosterone Matters for Women

Testosterone is not just a “male hormone.” Women rely on it for a wide range of critical functions throughout life, even though they produce it in smaller amounts. As natural testosterone levels fall due to age, surgical menopause, or medical conditions, the body and mind feel the effects.

Muscle Mass and Strength

Testosterone is vital for preserving lean muscle tissue. When levels decline, women often notice gradual muscle loss, slower metabolism, and increased body fat, even if lifestyle habits remain the same.¹ 

This loss can change a woman’s physical appearance, but more importantly, it can weaken core strength, reduce endurance, and heighten the risk of injury and chronic disease over time.

Brain Function and Cognitive Health

Testosterone directly impacts brain health by regulating neurotransmitter pathways that control memory, concentration, and emotional stability. Declining levels can lead to brain fog, mood swings, irritability, and even depressive symptoms.²

Many women notice these cognitive changes as they move through their 40s and beyond, often without realizing the connection to hormonal shifts.

Libido and Sexual Wellness

Sexual health is another area strongly linked to testosterone. The hormone drives libido and supports sexual responsiveness.³

When testosterone declines, women frequently experience a drop in sexual desire, difficulties with arousal, and reduced satisfaction. These can all impact emotional well-being and relationship dynamics.

Exploring BHRT as a Solution

For women experiencing symptoms related to low testosterone, bioidentical hormone replacement therapy (BHRT) can offer a potential path to relief.⁴ BHRT uses hormones identical to those naturally produced in the body, which can allow for more predictable results and fewer unwanted effects.

Pellecome supports providers by making it easier to incorporate BHRT into your practice with high-quality pellets and our patented delivery system. We also offer direct access to clinical guidance without contracts or procedural fees.

Expand Your Practice With Pellecome’s Nationwide Provider Network

Testosterone therapy can potentially help improve sexual desire, mood, energy, and quality of life in women when prescribed thoughtfully.

To learn how to become a provider, call Pellecome at 888-773-9969. Pellecome supports practices nationwide.

1. Osmancevic A, Allison M, Miljkovic I, Vella CA, Ouyang P, Trimpou P, et al. Exploring the relationships between sex hormones and abdominal muscle area and radiodensity in postmenopausal women: Insights from the Multi-Ethnic Study of Atherosclerosis. Maturitas [Internet]. 2025;194(108197):108197. Available from: http://dx.doi.org/10.1016/j.maturitas.2025.108197
2. Dratva MA, Banks SJ, Panizzon MS, Galasko D, Sundermann EE, Alzheimer’s Disease Neuroimaging Initiative. Low testosterone levels relate to poorer cognitive function in women in an APOE-ε4-dependant manner. Biol Sex Differ [Internet]. 2024;15(1):45. Available from: http://dx.doi.org/10.1186/s13293-024-00620-4
3. Weiss RV, Hohl A, Athayde A, Pardini D, Gomes L, Oliveira M de, et al. Testosterone therapy for women with low sexual desire: a position statement from the Brazilian Society of Endocrinology and Metabolism. Arch Endocrinol Metab [Internet]. 2019;63(3):190–8. Available from: http://dx.doi.org/10.20945/2359-3997000000152
4. Scott A, Newson L. Should we be prescribing testosterone to perimenopausal and menopausal women? A guide to prescribing testosterone for women in primary care. Br J Gen Pract [Internet]. 2020;70(693):203–4. Available from: http://dx.doi.org/10.3399/bjgp20X709265