If you feel like your memory isn’t as sharp, your energy doesn’t last through the day, or your mood has shifted, a hormone imbalance could be the reason. Symptoms like these are common in both men and women as hormone production changes with age.
Pellecome offers pregnenolone supplementation through licensed healthcare providers to help support those experiencing signs of hormonal decline. Founded by board-certified OB/GYN Dr. Enrique G. Jacome, Pellecome focuses on safe solutions for maintaining hormonal balance.
What Is Pregnenolone?
Pregnenolone is a naturally occurring substance in the body that acts as a precursor to many key hormones, including testosterone, estrogen, progesterone, and cortisol. Often referred to as a “pre-hormone,” it plays a central role in the production of stress, sex, and neuroactive hormones that influence physical, emotional, and cognitive function.
The body produces pregnenolone from cholesterol, primarily in the adrenal glands, but also in the brain and reproductive organs. When pregnenolone levels drop, it can disrupt the hormonal chain and contribute to a range of symptoms tied to hormone imbalance. Supporting healthy levels may help restore equilibrium across several systems.
What Are the Symptoms of Low Pregnenolone?
Because pregnenolone is a precursor for several other steroids and hormones in the body, deficiency can have a profound impact on several bodily functions.
Symptoms related to low pregnenolone include:
- Difficulties paying attention
- Memory loss
- Joint and muscle pain
- Hair loss
- Dry skin
- Excessive fatigue
- Decreased sex drive
What Do Pregnenolone Supplements Do?
Pregnenolone supplements help initiate the biochemical pathways that lead to the synthesis of other important hormones, including progesterone, estrogen, testosterone, and cortisol. These downstream hormones influence everything from metabolism and stress response to libido, cognitive performance, and joint health.
When the body’s natural pregnenolone levels decline, supplementation can help restore this first step in the hormone cascade. Over time, this support may improve the body’s ability to regulate mood, energy, focus, and physical resilience.
These changes will not be instantaneous. It may take three to four months to obtain optimal results through pregnenolone supplementation.
Is DHEA the Same as Pregnenolone?
DHEA (dehydroepiandrosterone), like pregnenolone, is a hormone precursor, but they are not the same thing.
DHEA, similar to many other hormones, is converted from pregnenolone.
Pregnenolone and DHEA are both necessary for the production of testosterone and estrogen. DHEA may also assist with cardiovascular health and bone density.
Due to their different functions and benefits, hormone therapy often includes both DHEA and pregnenolone supplementation.
Is Taking a Pregnenolone Supplement Safe?
Pregnenolone supplementation should only occur under the supervision of a qualified hormone specialist. Supplementation is linked to side effects, including:
- Rashes and acne
- Digestive issues
- Sleep disturbances
- General agitation
- Headache
Any discomfort that lasts for more than a few days should be brought to the attention of your healthcare provider. Discontinuing treatment can eliminate symptoms, but they may also self-correct, allowing you to continue therapy until maximum effectiveness has been reached.
There are certain risks with any hormone supplementation. Always start hormone supplementation under the supervision of an experienced and qualified specialist. This will allow any concerns that arise to be addressed quickly by a competent medical professional.
Who Is Allowed to Take Pregnenolone Supplements?
Most research reports that pregnenolone supplements are safest and most effective when taken for twelve weeks. Those looking to balance their hormones, restore pregnenolone levels, and get their life back on track by eliminating the symptoms that come from a lack of pregnenolone in their bodies will benefit from this supplement.
However, it is not recommended to take this supplement if you suffer from health conditions stemming from hormone sensitivities or other imbalances, such as breast cancer, uterine cancer, endometriosis, or uterine fibroids.1
If you are breastfeeding, pregnant, or planning to become pregnant, it is best to avoid the pregnenolone supplement during this time.
What Dosage of the Pregnenolone Supplement Do I Need to Take?
Pregnenolone is an influential hormone in the body and is not something people can naturally consume from foods. This is why it’s important to take pregnenolone supplements with great care.
For most users, the recommended dosage of pregnenolone supplements is 30mg a day. However, it is best to consult with your primary doctor about the specific dosage you may need to target your medical needs, hormonal imbalances, and other health conditions that can benefit from taking this supplement.2
What Are the Benefits of Taking Pregnenolone Supplements?
Because pregnenolone can have a major effect on the body, these supplements can help to improve the symptoms of many conditions, such as autism, bipolar disorder, and schizophrenia.
In addition, it can also help improve quality of life by supporting cognition, memory, and sleep while reducing symptoms of depression, stress, lack of cortisol, menopause, and andropause.3
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Why Choose Pellecome?
Pellecome was created to make hormone support safer, simpler, and more consistent for providers and the people they help. Founded by Dr. Enrique G. Jacome, a board-certified OB/GYN with decades of experience in hormone therapy, Pellecome is built on real clinical insight.
Our pregnenolone supplements are part of a system that’s been carefully developed to support hormone balance in a practical, straightforward way. Licensed providers who use Pellecome have access to training, tools, and resources that help them deliver better outcomes.
If you’re looking for a smarter approach to hormone support, Pellecome offers a clinically guided option trusted by professionals across the country.
Frequently Asked Questions
What Lab Tests Are Used to Measure Pregnenolone Levels?
Pregnenolone levels can be measured through a blood test, typically a serum pregnenolone assay. While this test is not always included in standard panels, it can be ordered by healthcare providers who are evaluating hormone status.
Some advanced hormone panels may also assess related markers to provide a more complete picture of hormone synthesis and conversion patterns.
Is Pregnenolone Safe for Long-Term Use?
When monitored and guided by a trained provider, pregnenolone supplementation is generally considered safe for long-term use.
Because pregnenolone influences the production of multiple downstream hormones, it’s important to check hormone levels regularly and adjust dosing as needed. Potential side effects can occur if dosing is too high or not well balanced with other therapies.
Can Pregnenolone Supplementation Affect Mood Disorders Such as Anxiety or Depression?
Emerging research suggests that pregnenolone may influence mood through its effects on neurosteroids and neurotransmitter activity in the brain. Some studies have shown benefits for individuals experiencing mood swings, anxiety, or depressive symptoms, especially when these are linked to hormonal changes.4
However, pregnenolone is not a replacement for psychiatric care and should be used as part of a broader strategy under professional supervision.
Are There Any Medications or Supplements That May Interfere With Pregnenolone?
Yes. Certain medications – including hormonal contraceptives, corticosteroids, and some psychiatric medications – may interfere with pregnenolone production or metabolism.
Additionally, supplements that influence hormone activity (such as DHEA, progesterone, or adaptogens) may alter how the body responds to pregnenolone. It’s important to share a full list of medications and supplements with your provider to avoid interactions or unintended effects.
What Is the Ideal Time of Day to Take Pregnenolone for Best Absorption and Effectiveness?
Pregnenolone is typically taken in the morning since it can influence energy, alertness, and cortisol production. Taking it early in the day may align more closely with the body’s natural hormone rhythms.
As with any supplement, timing and dosage should be individualized based on your provider’s guidance and your response over time.
Contact Us to Learn More
If you are interested in trying pregnenolone supplements, find a Pellecome provider in your area to learn how they could support your hormone health.
Healthcare professionals interested in offering Pellecome supplements and BHRT support can also reach out to us to explore provider resources, training opportunities, and product access. We welcome licensed providers who want to integrate safe, structured hormone support into their practice.
- WebMD. Pregnenolone - Uses, Side Effects, and More. Available from https://www.webmd.com/vitamins/ai/ingredientmono-98/pregnenolone
- Western New York Urology Associates. Pregnenolone: Principal Proposed Uses. Available from https://www.wnyurology.com/content.aspx?chunkiid=21848#:~:text=A%20typical%20recommended%20dosage%20of,as%20much%20as%20700%20mg.
- Cathy Wong. VeryWellMind. The Health Benefits of Pregnenolone. 7 Feb 2023. Available from https://www.verywellmind.com/the-lowdown-on-pregnenolone-89502
- Barbiero I, Bianchi M, Kilstrup-Nielsen C. Therapeutic potential of pregnenolone and pregnenolone methyl ether on depressive and CDKL5 deficiency disorders: Focus on microtubule targeting. J Neuroendocrinol [Internet]. 2022;34(2):e13033. Available from: http://dx.doi.org/10.1111/jne.13033
