You deserve to have the right tools to make losing weight easier and more sustainable. If you have tried diets, workouts, or other weight loss methods without lasting success, naltrexone is a non-habit-forming medication that can help. It lowers food cravings and supports better hormone balance.
Pellecome partners with healthcare providers across the U.S. to make therapies like naltrexone accessible in clinical practice. Through Pellecome’s distribution network and provider support programs, doctors and wellness professionals can integrate this treatment into their practices to expand services and improve patient outcomes.
If you are ready to take your first steps towards healthy weight management or if other weight loss methods have failed to produce results, please use our site to find a provider in your area and let us help you begin your journey towards optimal health today.
What Is Naltrexone?
Naltrexone was originally developed to block the effects of opioids, but research has shown that it can also play a role in weight management.
In lower doses, it influences your brain’s reward system and hormone activity in ways that reduce food cravings and make it easier to avoid overeating. Many patients also experience improvements in energy, mood, and sleep — all factors that support your long-term success when you're trying to lose weight.
Naltrexone works best as part of a comprehensive plan. Combined with daily movement, balanced nutrition, and sometimes additional support such as counseling, it can help reinforce healthy habits. Providers trained in prescribing naltrexone can personalize treatment to fit each patient’s health history and weight goals.
Who Is an Ideal Candidate for Naltrexone?
Naltrexone may be a good option for people who need extra support with weight management, but certain factors can influence eligibility. You may be an ideal candidate if:
- You are overweight or experiencing weight gain related to medical conditions
- You want a non-habit-forming option to support long-term weight management
- You are not currently dealing with active liver disease
- You are not taking medications that could interact negatively with naltrexone
- You are open about the supplements, herbs, and medications you use, so your provider can make a safe recommendation
Because each person’s health situation is different, the safest way to know if naltrexone is right for you is through a one-on-one consultation with a qualified provider.
What Are the Benefits of Naltrexone?
Naltrexone assists in healthy weight management. This, in turn, can improve your quality of life.
In a study published by the National Institutes of Health, naltrexone, combined with lifestyle changes and modest calorie reduction, was shown to produce “clinically significant weight loss.”
Furthermore, this has been shown to be the case even when weight gain is medically related.
Losing weight can positively impact both body and mind, including improved focus, better sleep, and a greater range of motion.
Equally important, losing weight reduces risks for several deadly diseases, such as diabetes, hypertension, heart disease, and certain types of cancer.
Are There Any Risks Associated With Naltrexone?
Naltrexone is considered safe and has been shown to benefit people struggling with excessive weight. It is not, however, without minor risks. These include:
- Nausea and dizziness
- Headache and bone/joint pain
- Sleep difficulties and restlessness
- Abdominal cramps
- Muscle aches
These side effects are uncommon and are typically very mild. The risks of naltrexone are generally less serious than the health consequences of obesity. Although rare, severe side effects of naltrexone may include liver damage. Let your provider know if you have a history of liver disease or have had elevated liver function tests in the past.
Why Choose Pellecome?
When it comes to your health, you deserve treatments backed by experience. Pellecome was created by Dr. Enrique G. Jacome, a board-certified OB-GYN who has specialized in hormone replacement therapy since 1995. After performing more than 30,000 pellet insertions, he developed a system that makes therapies like naltrexone easier to access through your healthcare provider.
Every provider who works with Pellecome is trained and supported with the tools they need to guide your care. From accurate dosing calculators to ongoing medical education, Pellecome ensures that the professionals offering these treatments have the knowledge and resources to give you the best possible outcomes.
By choosing a provider who partners with Pellecome, you can feel confident that your treatment is built on proven science and supported by a company fully committed to your health.
Frequently Asked Questions
How Often Should You Take Naltrexone?
Naltrexone pellets are implanted in the subcutaneous tissue, just like bioidentical hormone pellets. These pellets, depending on the dose, will block receptors for approximately 10-12 weeks.
Your doctor will decide the right dose and how often you should receive treatment. Longer-lasting options, like pellet implants, can make things easier since you do not have to remember to take a pill every day.
Can You Combine Naltrexone With Other Medications or Supplements?
Naltrexone should not be used with opiates, including cough syrup and other medications that may contain codeine. Alcohol and narcotics must be avoided while on naltrexone as well.
There are no known interactions with vitamins or minerals. Still, it is best to always inform your physician of the medications, supplements, herbs, and illicit drugs – including marijuana – you are using. This helps to guard against potential complications and can assist in more predictable and consistent outcomes.
How Is Naltrexone Administered?
Naltrexone can be administered through an injection or taken orally via pill. It depends on what the doctor recommends and your personal preference.
How Long Will I Need to Take Naltrexone?
The duration of treatment varies from patient to patient. While some people may take it for several months, others may need to take it for longer periods of time. Your duration of treatment will be decided based on your needs and what your healthcare provider feels is best.
Can Naltrexone Be Combined With Other Hormone Treatments?
Yes, naltrexone can often be combined with other therapies, but it depends on your individual health needs and any medications you are currently taking. That is why it is important to let your healthcare provider know about all prescriptions, supplements, and hormones you are using before starting treatment.
Many patients see the best results when naltrexone is paired with a broader wellness approach. For example, our PellecomeFIT® program combines bioidentical hormone replacement therapy (BHRT), peptides, and nutritional support with medications like naltrexone to improve body composition, control cravings, and restore hormonal balance. This type of integrated plan can make weight management more predictable and sustainable by addressing both the physical and hormonal factors that affect metabolism and appetite.
Your provider will work with you to decide if combining naltrexone with hormone therapy or other treatments is the most effective choice for your goals.
Is Naltrexone a Replacement for Weight Loss Therapy?
No, naltrexone is not a replacement for weight loss therapy. It is important to note that naltrexone is primarily used to treat alcohol and opioid dependence. However, in some cases, it is used off-label for weight management.
Can You Overdose on Naltrexone?
Although rare, it is possible to overdose on naltrexone if it is taken in excess. That is why it is imperative to use naltrexone only as directed by a licensed healthcare provider.
Is It Safe to Take Naltrexone While Pregnant?
The safety of naltrexone therapy while pregnant is not well-established. As such, be sure to inform your healthcare provider if you are pregnant or are planning on becoming pregnant in the near future.
How Long Does It Take to See Weight Loss Results With Naltrexone?
Results vary from person to person, but many patients begin noticing changes within the first few weeks. Because naltrexone works by lowering cravings and supporting hormone balance, the effects build gradually.
Consistency with treatment and healthy lifestyle choices, like improved eating habits and regular activity, usually leads to the best long-term results.
How Is Naltrexone Different From Other Weight Loss Medications?
Unlike stimulant-based medications that suppress appetite through the nervous system, naltrexone works on the brain’s reward pathways and hormone activity. This makes it non-habit-forming and often better tolerated for long-term use. It can also be paired with other wellness strategies to give you more sustainable support.
How Does Naltrexone Affect Metabolism & Appetite?
Naltrexone helps reduce food cravings by influencing the brain’s response to eating and reward signals. At the same time, it supports hormone balance, which can improve energy levels, lean muscle development, and overall metabolic function. Together, these effects make it easier for patients to control appetite and maintain healthier daily routines.
Find a Provider
If you are ready to learn how naltrexone, BHRT, and lifestyle changes can help you lose weight and keep it off, please use our directory to find an experienced physician in your area today.
Pellecome supplements and products are available through highly trained and experienced doctors, nurse practitioners, and other healthcare professionals dedicated to helping people live their best lives.
