Estrogen plays a central role in a woman’s health, from regulating menstrual cycles and maintaining bone density to supporting skin elasticity, brain function, mood, and cardiovascular health.
As estrogen levels begin to decline during perimenopause and menopause, many women experience disruptive physical, mental, and emotional symptoms. Hormone replacement therapy may help restore hormonal balance and reduce these negative effects.
Pellecome offers a clinically supported system for licensed providers to deliver bio-identical hormone replacement therapy (BHRT) via subcutaneous pellets. Designed by Dr. Enrique G. Jacome, a board-certified Ob-Gyn and hormone therapy specialist, the Pellecome method supports predictable dosing and improved patient comfort through a patented pellet delivery device.
Symptoms of Low Estrogen in Women
Declining estrogen levels have specific effects on women, including:
- Physical symptoms, such as vasomotor symptoms (night sweats, hot flashes, and flushes) and vaginal dryness.
- Metabolic and structural changes such as bone loss, skin thinning, fatty replacement of the breast, changes in blood lipids, and atrophy of the bladder and urethra.
- Vasomotor symptoms include hot flashes and night sweats, often considered to be the cardinal symptoms of menopause.
When to Consider BHRT as a Woman
Hormone levels shift naturally over time, but when those changes begin to interfere with daily life, it may be time to explore bio‑identical hormone replacement therapy (BHRT).
Many women first consider BHRT during perimenopause or menopause, when they start to notice the symptoms of declining estrogen and progesterone levels.
BHRT may also be considered by women who experience early menopause, have undergone a hysterectomy or oophorectomy, or continue to struggle with symptoms despite lifestyle changes. A qualified healthcare provider can evaluate symptoms, review hormone testing, and determine whether BHRT is an appropriate option based on individual health history and goals.
Hormone therapy is usually prescribed using the lowest effective dose and for only the amount of time that is needed based on clinical judgment and the needs of the individual patient.
Hormone Imbalance Test
The following tests can be used to evaluate for hormone imbalance:
- Serum or Blood Testing: Serum or blood can be used to test for hormone imbalance.
- Saliva Testing: The FDA and the North American Menopause Society have expressed concerns about the reliability of the values obtained in this manner.2
BHRT in Women
The desired effect of BHRT in women includes:
- Reduce mood swings, irritability, and emotional fluctuations associated with hormone decline.
- Prevent osteoporosis, bone thinning, and fracture risk.
- Minimize physical symptoms, such as vasomotor symptoms (night sweats, hot flashes, and flushes) and vaginal dryness.
- Reduce metabolic and structural changes such as bone loss, skin thinning, fatty replacement of the breast, changes in blood lipids, and atrophy of the bladder and urethra.
Progestin is a form of progesterone. Taking progestin helps reduce the risk of cancer of the uterus that occurs when estrogen is used alone. Estrogen plus progestin is sometimes called “combined hormone therapy” or simply “hormone therapy.” Estrogen-only therapy is sometimes called “estrogen therapy.”
Restore
Regenerate Renew
Pellet Therapy
Subcutaneous implants have been identified as a convenient and practical method for delivering drugs that provides greater assurance that patients will take the prescribed medication and may have a more predictable therapeutic outcome than other delivery methods.3
Studies have shown that there is a correlation between the time that the markers of hormone insufficiency return to normal and the time required for blood hormone levels to reach the end of the delivery from the pellet.
This steady, long-acting delivery method helps support consistent symptom relief without the daily maintenance required by other hormone therapies.
Benefits of Hormone Therapy for Women
Although the clinical effects of hormone optimization vary depending on the patient and the type of treatment, the objective for many women is to benefit from one or more of the following:
- Protection from Osteoporosis: Studies have found that estrogen has benefits for preventing bone loss and may defend against problems like osteoporosis or hip fractures in some patients.4
- Decreased hot flashes and night sweats: Clinical studies have shown that oral hormone replacement therapy is effective in alleviating hot flashes and night sweats, two of the most common symptoms associated with menopause and sleep disturbances.5
- Improved sex drive and reduced vaginal dryness: Up to 45 percent of menopause or postmenopausal women might be affected by vaginal atrophy, which causes symptoms like vaginal dryness, pain during sex, itching, irritation, burning, and discharge. Hormone replacement may be prescribed to alleviate these symptoms.6
Women may also experience:
- Increased lean body mass
- Decreased fat mass
- Increased bone mineral density
Why Choose Pellecome?
Pellecome was founded by Dr. Enrique G. Jacome, a board-certified Ob-Gyn and leading hormone therapy specialist who has placed over 30,000 implants. His goal was simple: to create a better, more consistent experience for both providers and patients.
With Pellecome, providers gain access to a patented insertion system designed to reduce bruising, improve comfort, and ensure accurate pellet placement. There are no contracts or procedure fees, and each practice receives ongoing clinical and marketing support, including access to ROI analysis tools, physician training, and a digital portal filled with resources tailored to your practice’s needs.
The pellets are crafted using bio-identical hormones and designed for reliable, long-lasting release. Thousands of women have already experienced the difference of hormone optimization guided by this trusted and clinically proven method.
Frequently Asked Questions
How Often Do Hormone Pellets Need to Be Replaced?
Hormone pellets typically release hormones steadily for about three to six months before absorption is complete and levels begin to decline. Most providers schedule replacement within this timeframe. Pellets are often effective for three to six months, though individual timing varies based on metabolism and hormone needs.
Are Hormone Pellets Used to Treat Progesterone Deficiency, or Just Estrogen?
Yes. Hormone pellets can be formulated with progesterone as well as estrogen, depending on a woman’s hormone profile and clinical goals. Progesterone is often included when estrogen therapy is used for women with a uterus to help protect the endometrium, though dosing and formulation are individualized through lab testing and clinical evaluation.
Will I Need to Stop Taking Other Medications When Starting BHRT?
There is no universal requirement to stop all other medications when beginning BHRT; however, some drugs may affect hormone metabolism (for example, certain anticonvulsants or corticosteroids).
A qualified provider will review all medications to ensure safety and avoid interactions. This should be discussed with your clinician. Specific drug‑hormone interactions are highly individualized and depend on the medication class.
What Kind of Training Do Pellecome Providers Receive?
Pellecome providers receive training specific to bio‑identical hormone pellet delivery, including instruction on patient selection, dosing protocols, and safe insertion technique using the patented delivery system. They also gain ongoing clinical resources, marketing support, and access to trainee portals designed to support practice integration.
Get Started with Pellecome
Pellecome simplifies the process of offering BHRT by giving providers a complete, ready-to-implement system that enhances patient care and streamlines delivery. With clinical resources, marketing support, and nationwide access to top-tier products, you can grow your practice with confidence.
Looking for treatment? Find a Pellecome provider near you.
- Hoffman BL. The Mature Woman. In: Williams Gynecology, 3e [Internet]. London, OH: McGraw Hill Higher Education; Available from: https://accessmedicine.mhmedical.com/content.aspx?bookid=1758§ionid=118170961
- North American Menopause Society. The 2012 hormone therapy position statement of: The North American Menopause Society. Menopause [Internet]. 2012;19(3):257–71. Available from: http://dx.doi.org/10.1097/gme.0b013e31824b970a
- Lin S, Chao PY, Chien YW, Sayani S, Kuma S, Mason M, et al. In vitro and in vivo evaluations of biodegradable implants for hormone replacement therapy: effect of system design and PK-PD relationship. AAPS PharmSciTech [Internet]. 2001;2(3):E16. Available from: http://dx.doi.org/10.1208/pt020316
- Stevenson J, medical advisory council of the British Menopause Society. Prevention and treatment of osteoporosis in women. Post Reprod Health [Internet]. 2023;29(1):11–4. Available from: http://dx.doi.org/10.1177/20533691221139902
- MacLennan A, Lester S, Moore V. Oral estrogen replacement therapy versus placebo for hot flushes: a systematic review. Climacteric [Internet]. 2001;4(1):58–74. Available from: http://dx.doi.org/10.1080/713605036
- Woods NF. An overview of chronic vaginal atrophy and options for symptom management. Nurs Womens Health [Internet]. 2012;16(6):482–93; quiz 494. Available from: http://dx.doi.org/10.1111/j.1751-486X.2012.01776.x
- Shan Y. The impact of corticosteroids on reproductive hormones: Understanding effects and implications [Internet]. Available from: https://www.primescholars.com/articles/the-impact-of-corticosteroids-on-reproductive-hormones-understanding-effects-and-implications.pdf
- Svalheim S, Sveberg L, Mochol M, Taubøll E. Interactions between antiepileptic drugs and hormones. Seizure [Internet]. 2015;28:12–7. Available from: http://dx.doi.org/10.1016/j.seizure.2015.02.022
